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该文对８９例死亡重型肝炎（重肝）患者（急重型２例，亚重型２０例，慢重型６７例）进行了病原学及单一、混合感染血清学分析。结果提示重肝以ＨＢＶ感染为主，目前大部分为慢重型，且以乙、丙型多见。前二者混合感染引起的重肝预后严重；在ＨＢＶ感染的基础上重叠ＨＥＶ是本病重型化的主要原因之一，而孕妇尤甚。同时不少重肝缺乏ＨＢＶ感染的血清学标志，除与病毒本身变异，尚与宿主的免疫应答及其它肝炎病毒的感染有关。
In this paper, 89 patients with severe hepatitis (severe hepatitis) died of severe acute type 2 cases, 20 cases of sub-heavy and 67 cases of chronic severe type were analyzed by serology and single and mixed infection. The results suggest that severe hepatitis with HBV infection, most of the slow-type, and B, C more common. Severe severe hepatitis caused by the combined infection of the former two patients has a serious prognosis. Overlapping HEV on the basis of HBV infection is one of the major causes of this type of severe disease, especially for pregnant women. At the same time, many serological markers of severe hepatitis with deficiency of HBV infection are related to the immune response of the host and other hepatitis viruses in addition to the mutation of the virus itself.