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目的:观察茵陈在治疗妊娠期肝内胆汁淤积症(ICP)的临床疗效,探讨其作用机理。方法:61例患者随机分为对照组和治疗组。对照组32例给予常规治疗。治疗组29例在对照组基础上加用茵陈煎剂口服,每日2次治疗,两组疗程均为3周。比较两组治疗前后血清总胆汁酸(TBA)、血清谷丙转氨酶(ALT)和谷草转氨酶(AST)的变化,观察两组妊娠结局和围产儿情况。结果:两组治疗前后TBA、AST和ALT的差值比较,差异有统计学意义(P<0.05);治疗组新生儿窒息及羊水粪染率低于对照组(P<0.05);对照组妊娠终止时间明显早于治疗组(P<0.01),剖宫产率高于治疗组(P<0.05)。瘙痒、黄疸明显减轻,对照组缓解慢。结论:常规治疗加用茵陈治疗妊娠期肝内胆汁淤积症安全有效,能明显改善患者妊娠结局。
Objective: To observe the clinical effect of capillaris in the treatment of intrahepatic cholestasis of pregnancy (ICP) and to explore its mechanism. Methods: 61 patients were randomly divided into control group and treatment group. Control group, 32 cases given conventional treatment. In the treatment group, 29 cases were treated with acinar decoction orally on the basis of the control group twice daily, and both courses of treatment were 3 weeks. The changes of serum total bile acid (TBA), serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the two groups before and after treatment were compared. The pregnancy outcome and perinatal condition were observed in both groups. Results: The differences of TBA, AST and ALT between the two groups before and after treatment were statistically significant (P <0.05). The rates of neonatal asphyxia and amniotic fluid meningitis in the treatment group were lower than those in the control group (P <0.05) The termination time was significantly earlier than the treatment group (P <0.01), cesarean section rate was higher than the treatment group (P <0.05). Pruritus, jaundice significantly reduced, slow relief in the control group. Conclusion: Conventional treatment with capillaris is safe and effective in treating intrahepatic cholestasis of pregnancy, which can significantly improve the pregnancy outcome.