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目的:研究奥卡西平(Oxcarbazepine,OXC)对大鼠三叉神经节神经元钙电流的调控作用。方法:SD大鼠随机分为3组(n=8):生理盐水组(NS组),致炎剂组(IS组),OXC预防组。应用膜片钳技术,采用全细胞记录方式,观察OXC对偏头痛大鼠急性分离的三叉神经节的高电压激活钙电流(HVA-ICa)的调控作用。结果:OXC能够抑制钙电流,使钙电流的激活曲线向去极化方向移动,使钙电流的失活曲线向超级化方向移动。结论:OXC可能通过抑制钙离子进入细胞膜,来预防偏头痛的发作。同时OXC可能对外周神经系统及伤害感受的传入的兴奋性起到调控作用。
AIM: To investigate the regulatory effect of Oxcarbazepine (OXC) on the calcium currents of trigeminal ganglion neurons in rats. Methods: SD rats were randomly divided into 3 groups (n = 8): saline group (NS group), anti-inflammatory group (IS group) and OXC prevention group. Patch clamp technique was used to observe the regulatory effect of OXC on HVA-ICa in acutely isolated trigeminal ganglion in migraine rats. Results: OXC can inhibit the calcium current, the activation curve of calcium current to depolarization direction, the calcium current inactivation curve to the direction of the super-shift. Conclusion: OXC may prevent the onset of migraine by inhibiting the entry of calcium ions into the cell membrane. At the same time, OXC may regulate the afferent excitability of peripheral nervous system and nociception.