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本文主报道我所合成室以三烃基蒽环酮为原料、苄胺作侧链进行A环和C_1C_4的取代而得到(87-9)MIX·HCL化合物体外内抗肿瘤活性试验的结果。在体外,3~H-TdR渗入P388白血病细胞DNA合成抑制试验表明(87-9)MIX·HCI有较强的抑制作用、当化合物浓度为100μg/ml、10μg/ml时,其抑制率分别达97.7％、22.5％。此活性几乎
In this paper, we report that the antitumor activity of (87-9) MIX · HCL compounds in vitro was tested in vitro using trihydrocarbanone as starting material and benzylamine as side chain to replace A ring and C_1C_4. In vitro, inhibition of 3-H-TdR incorporation into DNA synthesis of P388 leukemia cells showed that (87-9) MIX · HCI had a strong inhibitory effect. When the compound concentration was 100μg / ml and 10μg / ml, the inhibitory rates were 97.7%, 22.5%. This activity is almost