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急性重症胰腺炎（ SAP）常伴随器官功能障碍，而肠道是最早发生功能障碍的器官，最初以肠道动力障碍最常见，进一步可能出现中毒性肠麻痹、腹腔间隔室综合征、胰腺坏死组织感染，甚至导致多器官功能衰竭。因此，探索SAP时肠道动力障碍的机制至关重要，而SAP出现肠道功能障碍的原因可能与胃肠激素比例失调、神经调节、胃肠道 Cajal间质细胞、肠道缺血／再灌注损伤、炎症反应、内毒素血症、胰腺炎相关性腹水等相关。“,”Severe acute pancreatitis(SAP) is often associated with organ dysfunction.Intestinal tract is the most common and earliest organ presenting dysfunction.Intestinal motility disorder is the most common symptom in intestinal tract,which may further deteriorate into toxic intestinal paralysis,abdominal compart-ment syndrome, pancreatic necrosis tissue infections and multiple organ failure .Therefore, exploring the mechanisms of intestinal motility disorders of SAP is essential .The reasons for SAP associated intestinal dys-function may be related to gastrointestinal induced neural hormone imbalance ,neural regulation,gastrointesti-nal Cajal interstitial cells,intestinal ischemia/reperfusion injury,inflammatory reaction,endotoxemia,pancre-atitis associated ascites and so on.