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[目的]探讨CAP2 基因在肝细胞癌(HCC)中的表达水平及对预后的评估价值.[方法]在 Oncomine数据库筛选 HCC相关基因CAP2,接着在 Oncomine和 CCLE数据库进行二次分析,在 GEPIA数据库进行预后分析.[结果]基于 Oncomine数据库,对 HCC miRNA芯片分析显示,CAP2 在 HCC基因表达谱中上调最显著.共有412 种不同的CAP2 研究被收录于 Oncomine数据库中,其中具有统计学意义的 CAP2 研究有 33 项,33 项中CAP2 高表达的有 14项研究,低表达的有 19 项研究.共有 8 项研究发现 CAP2 在 HCC组织中处于高表达水平(P ＜0.05),共646 个样本;接着采用CCLE数据验证CAP2 在肝癌细胞表达水平,结果显示与 Oncomine一致,均是高表达.CAP2 与 HCC患者的无病生存率存在相关性(P ＜0.05),与总生存率不相关(P ＞0.05);高表达CAP2 患者的无病生存率较差,低表达 CAP2 患者的无病生存率较好.[结论]CAP2 在 HCC的组织和细胞中均处于高表达水平,且与 HCC预后相关,为 HCC新的诊断和预后提供生物标志物.“,”[Objective]To investigate the expression of CAP2 gene in HCC and its prognostic value.[Methods]The HCC related gene CAP2 was screened in Oncome database,and then the secondary analysis was carried out in Oncome and CCLE database,and the prognosis analysis was carried out in gepia database.[Results]Based on Oncome database,the analysis of HCC miRNA microarray showed that CAP2 was upregulated most significantly in HCC gene expression profile.A total of 412 different CAP2 studies were included in oncoming database,among which 33 were statistically significant,14 were highly expressed,and 19 were low expressed.A total of 8 studies found that CAP2 was highly expressed in HCC (P＜0.05),a total of 646 samples;then CCLE data was used to verify the expression level of CAP2 in HCC cells,and the results showed that CAP2 was highly expressed,consistent with oncomine.There was correlation between CAP2 and the diseasefree survival rate of HCC patients (P ＜0.05),but not with the overall survival rate (P ＞0.05);the diseasefree survival rate of patients with high expression of CAP2 was poor,and the diseasefree survival rate of patients with low expression of CAP2 was better.[Conclusion]CAP2 is highly expressed in HCC tissues and cells,and is related to the prognosis of HCC.It provides biomarkers for the new diagnosis and prognosis of HCC.