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目的探讨羊水表皮生长因子浓度与胎儿肺泡成熟度的关系。 方法对 16 8例胎龄在 2 1～ 42周的孕妇 ,采用羊膜腔穿刺术采集羊水。分别以薄层层析法和放射免疫法测定卵磷脂 /鞘磷脂比值 (L/S)和表皮生长因子(EGF)。 结果羊水L/S比值及EGF浓度均与胎龄呈正相关 (r值分别为 0 .86和 0 .87,P值均 <0 .0 1)。羊水EGF浓度与L/S比值有显著的相关性 (r =0 .76 ,P <0 .0 0 1)。 结论羊水表皮生长因子与胎儿肺泡成熟度密切相关。
Objective To investigate the relationship between amniotic fluid epidermal growth factor and fetal alveolar maturity. Methods 168 pregnant women with gestational age of 21 to 42 weeks were enrolled in the study. Amniocentesis was collected by amniocentesis. Lecithin / sphingomyelin ratio (L / S) and epidermal growth factor (EGF) were determined by TLC and radioimmunoassay respectively. Results The amniotic fluid L / S ratio and EGF concentration were positively correlated with gestational age (r = 0.86 and 0.87, P <0.01). Amniotic fluid EGF concentration and L / S ratio was significantly correlated (r = 0.76, P <0.001). Conclusion Amniotic fluid epidermal growth factor and fetal alveolar maturity are closely related.