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骨桥蛋白(OPN)是分泌性细胞的细胞外基质蛋白,与细胞的多种生理功能关系密切。越来越多的学者在乳腺癌、肺癌、前列腺癌和结肠癌的研究中发现,OPN在肿瘤的发生、侵袭以及转移过程中发挥着重要的作用。大量的文献报道,OPN在头颈部的正常黏膜中无表达,而在发育不良和鳞状细胞癌的组织中呈阳性表达,且表达水平与肿瘤的转移和恶性程度有关。希望在不久的将来,OPN能够作为靶点用于鳞状细胞癌的治疗。
Osteopontin (OPN) is an extracellular matrix protein secreted by cells and has many physiological functions. More and more scholars in breast cancer, lung cancer, prostate cancer and colon cancer research found that OPN plays an important role in tumorigenesis, invasion and metastasis. A large number of literatures reported that OPN was not expressed in normal mucosa of head and neck, but positive in tissues of dysplasia and squamous cell carcinoma. The expression of OPN was correlated with tumor metastasis and malignancy. Hopefully in the near future, OPN can be used as a target for the treatment of squamous cell carcinoma.