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报道了麦白霉素对５７１株Ｇ＋菌、Ｇ－菌及厌氧菌的体外抗菌作用。结果表明，麦白霉素对金葡菌、表皮葡萄球菌中的红霉素敏感菌有较好的抗菌作用，其抗菌活性与进口麦迪霉素相同，比红霉素略低，ＭＩＣ５０和ＭＩＣ９０分别为０．５、１和４、２ｍｇ／Ｌ；同时还对部分红霉素耐药的金葡菌、表皮葡萄球菌有一定抗菌作用，最低ＭＩＣ值分别可达０．５和１ｍｇ／Ｌ。对肺炎链球菌、化脓链球菌、细小链球菌和淋病奈瑟氏球菌等其它常见临床致病菌也有一定的抗菌作用，ＭＩＣ５０在０．２５～１ｍｇ／Ｌ之间。对Ｇ＋及Ｇ－厌氧菌均有较强的抗菌活性，ＭＩＣ５０在０．１２５～０．５ｍｇ／Ｌ之间，其中对消化链球菌、脆弱类拟杆菌属和其它Ｇ－厌氧菌的ＭＩＣ９０分别为０．２５、８、４ｍｇ／Ｌ；其抗菌活性与进口麦迪霉素相同或稍好。Ｇ＋菌对麦白霉素的耐药率在２１．４３％～６８％之间，总耐药率为２９．５７％。杀菌实验结果表明，麦白霉素对金葡菌、表皮葡葡球菌、化脓性链球菌和肺炎链球菌的ＭＢＣ５０值比其ＭＩＣ５０值高１６～２５６倍，且无明显杀菌作用，为一典型抑菌药。其他实验显示，ｐＨ值对麦白霉素的抗菌活性影响较大，在偏碱条件下活性较高；接种量对麦白霉素的抗菌活性影响随菌种不同而?
The in vitro antibacterial activity of wheat levomycin against 571 G + bacteria, G- bacteria and anaerobic bacteria was reported. The results showed that the mycobactant against Staphylococcus aureus, Staphylococcus epidermidis erythromycin sensitive bacteria have good antibacterial activity, the antibacterial activity of imported midecamycin same, slightly lower than the erythromycin, MIC50 and MIC90 respectively 0.5, 1 and 4, 2mg / L; At the same time also some erythromycin-resistant Staphylococcus aureus, Staphylococcus epidermidis have some antibacterial effect, the minimum MIC values were up to 0.5 and 1mg / L. Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus mutans and Neisseria gonorrhoeae and other common clinical pathogens also have some antibacterial effect, MIC50 in the 0.25 ~ 1mg / L between. On G + and G-anaerobic bacteria have strong antibacterial activity, MIC50 between 0.125 ~ 0.5mg / L, of which Peptostreptococcus, Bacteroides fragilis and other G-anaerobic MIC90 Respectively, 0.25,8,4 mg / L; its antibacterial activity and the import of midecamycin same or slightly better. The resistance rates of G + to malimite were between 21.43% ~ 68%, and the total drug resistance rate was 29.57%. The results of bactericidal test showed that the MBC50 value of melemomycin against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes and Streptococcus pneumoniae was 16 ~ 256 times higher than its MIC50 value, and showed no obvious bactericidal effect Bacterial medicine. Other experiments show that the pH value of the greater impact of antibacterial activity of malaomycin, higher activity in the partial alkali conditions; inoculum on the antibacterial activity of malaomycin with different bacteria?