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目的：探索羟基喜树碱(HCPT)、顺铂(DDP)联合化疗对复发、远处转移鼻咽癌(NPC)的近期疗效。方法：对鼻咽癌远处转移患者17例，给予HCPT、DDP联合化疗，21d为一周期，应用2周期以上者评价疗效。结果：总有效率为76．47%，其中CR17．65%、PR58．82%，对复治转移者仍有75%的疗效。主要毒副反应为骨髓抑制，恶心呕吐、腹泻，但均可耐爱。结论：HCPT与DDP联合对晚期NPC是有效的化疗方案，值得临床进一步观察。
Objective: To explore the short-term curative effect of HCPT and DDP combined with chemotherapy on recurrence and distant metastasis of nasopharyngeal carcinoma (NPC). Methods: Seventeen patients with distant metastasis of nasopharyngeal carcinoma were treated with HCPT and DDP combined with chemotherapy for 21 days. The patients were treated with more than two cycles to evaluate the efficacy. Results: The total effective rate was 76.47%, of which CR17.65%, PR58.82%, the recurrence and treatment of relapse were still 75% of the effect. The main side effects of bone marrow suppression, nausea, vomiting, diarrhea, but can be resistant to love. Conclusion: The combination of HCPT and DDP is an effective chemotherapy regimen for advanced stage NPC, which is worth further clinical observation.