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Objective:The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer(NSCLC) and the impact on V20 and radiation pneumonitis(RP).Methods:Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy(4000 cGy).Forty patients got at least 25% tumor reduction were randomly divided into two groups:group A of regular shrink field radiotherapy(20 cases) and group B of CT/CT image fused shrink field radiotherapy(20 cases).Dosage reached 6600 cGy.Clinical data,V20 and RP were observed within 3 months after radiotherapy.Statistical analysis was conducted for the NSCLC patients.Results:22.5%(9/40) patients got RP during follow-up.Group A accounted for 6 cases(30%),and group B had 3 cases(15%).There was no marked difference between the two groups(P = 0.256),univariate analysis revealed that the IV20 of A and B groups,and IV20 and CV20 of all patients were statistically related to the incidence of RP(P < 0.05).With Wilcoxon method assay,the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups(P < 0.05).Conclusion:The CT/CT image infusion treatment planning could increase the radical dosage with better tumor control probability but won’t increase adverse reaction.
Objective: The aim of our study was to investigate the value of CT / CT image fusion radiation treatment planning in non-small cell lung cancer (NSCLC) and the impact on V20 and radiation pneumonitis (RP). Methods: Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy (4000 cGy). Forty patients got at least 25% tumor reduction were randomly divided into two groups: group A of regular shrink field radiotherapy (20 cases) and Group B of CT / CT image fused shrink field radiotherapy (20 cases) .Dosage reached 6600 cGy. Clinical data, V20 and RP were observed within 3 months after radiotherapy. Statistical analysis was conducted for the NSCLC patients. Results: 22.5% (9 / 40) patients got RP during follow-up.Group A accounted for 6 cases (30%), and group B had 3 cases (15%). There was no marked difference between the two groups (P = 0.256), univariate analysis revealed that the IV20 of A and B groups, and IV20 and CV20 of The Wilcoxon method assay, the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups (P <0.05) .Conclusion: The CT / CT image infusion treatment planning could increase the radical dosage with better tumor control probability but will not increase adverse reaction.