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本文报告287例使用地戈辛(D)维持剂量治疗的充血性心力衰竭患者,并结合863次血清地戈辛浓度(SDC)的测定结果进行分析。结果表明:D 0.25mg/d 适用于大部份病人,但高龄患者洋地黄中毒率高达16.6%;D0.125mg/d 适用于50岁以上及伴有心肌炎症的患者,但对年轻患者不适宜;D0.125mg 与0.25mg 隔日交替服用可能也是一种较为理想的治疗方法;D0.5mg/d 是一种不适宜的维持剂量;在维持剂量治疗中仍应严密观察病情,定期测定 SDC。
In this paper, 287 patients with congestive heart failure treated with defocusin (D) were reported and analyzed in combination with 863 serum digoxin concentrations (SDC). The results showed that: D 0.25mg / d for most patients, but older patients with digitalis poisoning rate as high as 16.6%; D0.125mg / d for more than 50 years of age and patients with myocardial inflammation, but not suitable for young patients ; D0.125mg and 0.25mg alternating alternate may also be a more ideal method of treatment; D0.5mg / d is an inappropriate maintenance dose; maintenance dose therapy should be closely observed in the disease, regular determination of SDC.