论文部分内容阅读
[目的]分析大连市区1991～2010年大肠癌流行趋势,为大肠癌防治措施的制定提供依据。[方法]根据大肠癌新发病例资料,分析其组织学类型,计算粗发病率、世界人口调整发病率(世标率)、截缩率、累积率、年度变化百分比(APC%),并进行年龄、时期、队列三因素相互调整后的相对危险度(RR)和95%可信区间估计,综合分析大肠癌年龄—时期—队列三因素变化趋势。[结果]男、女性大肠癌粗发病率分别为29.4/10万和23.3/10万,世标率分别为21.7/10万和15.6/10万,35～64岁截缩率分别为26.43/10万和22.48/10万,0～64岁累积率分别为0.99%和0.84%,0～74岁累积率分别为2.85%和1.91%。1991～2010年男女性粗发病率的APC均为+7.788%(P<0.001),世标率的APC分别为+4.603%(P<0.001)和+4.498%(P<0.001)。男女性在1996～2000年、2001～2005年和2006～2010年三个时期发病风险呈增加趋势(P<0.001)。1946年以后出生队列发病风险呈降低趋势(P<0.001)。35岁以上发病风险呈增加趋势(P<0.001)。[结论]大连市区大肠癌发病水平处于同期中国肿瘤登记城市地区较高水平,开展积极有效的全人群大肠癌防治势在必行。
[Objective] To analyze the epidemic trend of colorectal cancer in Dalian from 1991 to 2010 and provide the basis for the prevention and treatment of colorectal cancer. [Methods] According to the newly diagnosed cases of colorectal cancer, the histological types were analyzed, the crude incidence rate, world population adjusted incidence rate (world standard rate), truncation rate, cumulative rate, annual change percentage (APC% Age, age, cohort adjusted for relative risk (RR) and 95% confidence interval estimates, comprehensive analysis of colorectal cancer age-period-cohort three-factor trend. [Results] The crude incidence rates of colorectal cancer in men and women were 29.4 / lakh and 23.3 / lakh respectively, the world standard rates were 21.7 / lakh and 15.6 / lakh respectively, and the truncation rates of 35-64 larvae were 26.43 / 10 The cumulative rates were 0.99% and 0.84% for those aged between 0 and 64, respectively, and the cumulative rates for 0- to 74-year olds were 2.85% and 1.91% respectively. The crude APC rates of men and women between 1991 and 2010 were all + 7.788% (P <0.001). The rates of world standard APCs were + 4.603% (P <0.001) and + 4.498% (P <0.001) respectively. Men and women in 1996 and 2000, 2001 to 2005 and 2006 to 2010 the three stages of increased risk of onset (P <0.001). The incidence of birth cohort after 1946 showed a decreasing trend (P <0.001). The risk of developing over the age of 35 showed an increasing trend (P <0.001). [Conclusion] The incidence of colorectal cancer in urban area of Dalian is at a high level in China’s urban areas registered for cancer registration in the same period, and it is imperative to carry out active and effective prevention and treatment of colorectal cancer in the entire population.