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目的:观察益气养阴活血汤联合西药治疗气阴两虚兼血瘀型糖尿病肾病患者的临床疗效。方法:抽取本院72例气阴两虚兼血瘀型糖尿病肾病患者作为研究对象,随机分为2组各36例。研究组给予益气养阴活血汤联合常规西药治疗,对照组仅给予常规西药治疗,2组均以15天为1疗程,连续治疗4疗程。比较2组的临床疗效与治疗前后血糖[空腹血糖(FBG)、餐后2 h血糖(P2h BG)及糖化血红蛋白(Hb A1c)]、肾功能指标[尿微量白蛋白排泄率(UAER)、血肌酐(SCr)及24 h尿白蛋白排泄率(24h UAE)]的情况。结果:治疗后,研究组与对照组总有效率分别为91.67%、66.67%,2组比较,差异有统计学意义(P<0.05)。2组FBG、P2h BG、Hb A1c与UAER、SCr、24h UAE水平均较治疗前降低(P<0.05),研究组各项指标值均低于对照组(P<0.05)。结论:采用益气养阴活血汤联合西药治疗气阴两虚兼血瘀型DN疗效确切,可降低血糖,改善患者的肾功能,效果优于仅用常规西药治疗。
Objective: To observe the clinical efficacy of Yiqi Yangyin Huoxue Decoction combined with western medicine in treating patients with Qi-Yin deficiency and blood stasis type diabetic nephropathy. Methods: A total of 72 patients with Qi-Yin Deficiency and Blood Stasis Diabetic Nephropathy were selected as study subjects and randomly divided into two groups of 36 cases each. The study group was given Yiqi Yangyinhuoxue Decoction combined with conventional western medicine, while the control group only given conventional western medicine. The two groups were given 15 courses for one course of treatment for 4 courses. The clinical effects of two groups were compared before and after treatment with fasting blood glucose (FBG), 2h postprandial blood glucose (Hb A1c), and renal function indexes (urinary albumin excretion rate (UAER), blood Creatinine (SCr) and 24 h urinary albumin excretion rate (24h UAE)] situation. Results: After treatment, the total effective rate of study group and control group was 91.67% and 66.67%, respectively. There was significant difference between the two groups (P <0.05). The levels of FBG, P2h BG, Hb A1c, UAER, SCr and 24h UAE in the two groups were significantly lower than those before treatment (P <0.05). The indexes in the study group were lower than those in the control group (P <0.05). Conclusion: The treatment of qi and yin deficiency and blood stasis type DN with Yiqi Yangyin Huoxue Decoction combined with western medicine has definite curative effect, which can lower blood sugar and improve renal function of patients. The effect is better than that of conventional western medicine.