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应用双抗体夹心CELISA法动态检测了45例戊型病毒怀肝炎患者血清IL-8含量，研究发现：戊型病毒性肝炎急性期IL－8水平明显升高，与正常对照，恢复期相比处于高活性状态；IL－8水平与ALT呈明显相关（r＝0.5762，P＜005）。IL-8水平与BIL呈明显正相关（r=05064，P＜0.01），提示：IL-8与戊型肝炎的肝细胞损伤及炎症程度相一致；重症型较贫症患者血清IL－8升高更明显，有显著性差异（P＜0.01），提示：IL－8参与戊型肝炎的免疫病理损伤，监测IL～8水平可判定患者的预后和转归.
The level of IL-8 in serum of 45 hepatitis E patients with hepatitis E was detected dynamically by double antibody sandwich CELISA. The results showed that the level of IL-8 in acute hepatitis E virus group was significantly higher than that in control and recovery Highly active state; IL-8 level was significantly correlated with ALT (r = 0.5762, P <005). The level of IL-8 was positively correlated with BIL (r = 05064, P <0.01), suggesting that IL-8 is consistent with hepatocellular injury and inflammation in HEV patients. Serum IL-8 (P <0.01), suggesting that IL-8 is involved in the immunopathological damage of hepatitis E and the prognosis and prognosis of patients can be judged by monitoring the level of IL-8.