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目的:研究产自云南省香格里拉地区的腺叶香茶菜(Isodon adenolomus)地上部分的化学成分;方法:利用正反相硅胶、高效液相色谱等现代分离技术进行分离;通过IR,UV,MS,NMR等波谱方法鉴定了化合物结构式;对化合物1进行了单晶X-衍射分析,确定了其绝对构型;化合物2-5和10进行了细胞毒活性测定;结果:分离得到7个对映-贝壳杉烷二萜,1个对映-松香烷二萜和两个松香烷二萜;结论:Isoadenolins M-O(1-3)为新化合物,且化合物2-4和10表现出了一定细胞毒活性。
OBJECTIVE: To study the chemical constituents in the aerial parts of Isodon adenophorum from Shangri-La, Yunnan Province. Methods: The constituents were separated by modern separation techniques, such as silica gel, RP-HPLC and high performance liquid chromatography (HPLC) , NMR and other spectroscopic methods to identify the structural formula; Compound 1 was analyzed by single crystal X-ray diffraction to determine the absolute configuration; Compounds 2-5 and 10 cytotoxicity assay; Results: - Kaurene diterpene, 1 enantiomer - rosin diterpene and two rosin diterpenes; Conclusion: Isoadenolins MO (1-3) is a new compound, and compounds 2-4 and 10 showed a certain cytotoxicity active.