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实验证明广泛肝切除后的肝功能衰竭与肝能量负荷的显著减少有关。尽管在术后常用糖耐量试验测定肝能量代谢,但对残肝能量的动态变化却无精确的测定方法。肝内酮体比例,即乙酰乙酸与3-羟丁酸之比和肝线粒体游离辅酶Ⅰ与辅酶Ⅰ脱氢酶之比是相称的。由于乙酰乙酸和3-羟丁酸可以自由通过细胞膜,故动脉血中此两者之比可以作为肝酮体比值的指标,
Experiments show that extensive hepatectomy after liver failure and liver energy load significantly reduced. Although postmortem glucose tolerance test is commonly used to measure liver energy metabolism, there is no accurate method to determine the dynamic changes of residual liver energy. The proportion of intrahepatic ketones is proportional to the ratio of acetoacetate to 3-hydroxybutyrate and the ratio of free coenzyme I to coenzyme I dehydrogenase in the mitochondria of the liver. Since acetoacetate and 3-hydroxybutyrate are free to pass through the cell membrane, the ratio of arterial blood to that of both can be used as an indicator of hepatic ketone ratio,