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目的:探讨抗精子抗体(AsAb)、抗心磷脂抗体(ACA)与不孕不育的关系。方法:采用酶联免疫吸附(ELISA)法检测434例男性不育患者血清中的AsAb;892例女性不孕不育患者及40例正常对照组血清中的AsAb及ACA抗体。结果:①1326例不孕不育患者中抗精子总抗体的阳性率为21.4%,高于对照组7.5%,与正常对照组相比差异有统计学意义。其中男性抗精子总抗体的阳性率为23.6%;女性抗精子总抗体的阳性率为20.4%。②ACA的总阳性率为36.6%(643/1756),与正常对照组相比差异有统计学意义。结论:AsAb、ACA检测有助于临床免疫性不孕症的诊断,可为免疫性不孕不育患者诊断及治疗提供实验室依据。
Objective: To investigate the relationship between antisperm antibody (AsAb), anticardiolipin antibody (ACA) and infertility. Methods: AsAb in 434 male infertile patients and AsAb and ACA in 892 female infertility patients and 40 normal controls were detected by enzyme-linked immunosorbent assay (ELISA). Results: ① The positive rate of total anti-sperm antibody in 1326 infertility patients was 21.4%, which was higher than that in control group (7.5%). There was significant difference compared with normal control group. The positive rate of male anti-sperm total antibody was 23.6%. The positive rate of female anti-sperm total antibody was 20.4%. The total positive rate of ACA was 36.6% (643/1756), which was significantly different from the normal control group. Conclusion: AsAb and ACA are helpful to the diagnosis of clinically immunologic infertility and provide a laboratory basis for the diagnosis and treatment of infertility infertility patients.