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目的:评估英格兰、苏格兰和威尔士儿童及青年人癫痫发病率及患病率。设计:对1958年3月3日至9日间生于英格兰、苏格兰和威尔士的17 414名儿童作前瞻性研究,分别于7岁、11岁、16岁及23岁进行随访。在28岁时对伴有癫痫的患者进行了回顾。研究对象:23岁或23岁前发病的癫痫患者。研究结果判定的主要指标:癫痫的年龄特异性发病率、累积发病率和患病率。结果:23岁前确诊为癫痫的有124人(累积发病率为8.4/1 000;95%的可信区间为6.8到10.0),死亡6人。除癫痫外还具有神经系统缺陷或其他疾病者46人(37%)。23岁时活动性癫痫的患病率为6.3/1000(4.9～7.7/1 000)。结论:癫痫包括了多种惊厥发作形式。1/3的病例为全身性发作。只有1/4的病例其发病可以归于特定的病因。合并其他疾病者比无合并症者,其惊厥发作更易持续至青年期。1/8患者的药物治疗持续至发作停止后6年或6年以上。所有死亡病例均大于16岁。
Purpose: To assess the prevalence and prevalence of epilepsy among children and young people in England, Scotland and Wales. Design: A prospective study of 17 414 children born in England, Scotland and Wales between March 3 and March 9, 1958 was conducted at 7, 11, 16 and 23 years of age respectively. At age 28, patients with epilepsy were reviewed. Participants: Epilepsy patients aged 23 or 23 years old. The main indicators of the findings of the study: age-specific incidence of epilepsy, cumulative incidence and prevalence. Results: Twenty-four people were diagnosed with epilepsy before the age of 23 (cumulative incidence 8.4 / 1,000; 95% confidence interval 6.8 to 10.0) and 6 deaths. Forty-six people (37%) had neurological deficits or other diseases in addition to epilepsy. The prevalence of active epilepsy at age 23 was 6.3 / 1000 (4.9-7.7 / 1,000). Conclusion: Epilepsy includes several forms of seizures. One third of the cases were generalized. Only a quarter of cases its incidence can be attributed to a specific cause. Patients with other diseases than without complications, their seizures more likely to persist until adolescence. One-eighth of patients’ medication continued until six or more years after the onset of cessation. All deaths were greater than 16 years old.