间充质干细胞免疫学特性及其在自身免疫病中的应用基础研究进展

• 作 者: 薛利敏 薛群
• 机 构: 苏州大学附属第一医院神经内科,
• 出 处: 中华细胞与干细胞杂志(电子版)
• 发表日期: 2012年03期
• 关键词: 间充质干细胞 自身免疫病 免疫学特性 连续传代培养 诱导分化 发育早期 种子细胞 组织器官损伤 小肠细胞 软骨细胞

间充质干细胞(mesenchymal stem cell,MSC)是干细胞家族的重要成员,来源于发育早期的中胚层,主要存在于全身结缔组织器官中。人体和动物体内除存在于骨髓中外,还存在于羊膜[1]、脐带、脐血、胎肝、胎盘[2]、外周血、皮肤和脂肪等组织中,具有多向分化潜能,能分化为成骨细胞、软骨细胞和脂肪细胞等,在适宜条件下也可向神经细胞、上皮细胞、肝、肺和小肠细胞等诱导分化,且在连续传代培养和冷冻保存后仍具有多向分化潜能,可作为理想的种子细胞用于衰老和病变引起的组织器官损伤修复。

Mesenchymal stem cells (MSCs) are important members of the stem cell family. They are derived from the mesoderm of early development and mainly present in the connective tissue of the whole body. Except in the bone marrow, human and animal bodies also exist in amnion [1], umbilical cord, cord blood, fetal liver, placenta [2], peripheral blood, skin and adipose tissue, Osteoblasts, chondrocytes and adipocytes can also induce differentiation to nerve cells, epithelial cells, liver, lung and small intestine cells under suitable conditions, and they still have multi-directional differentiation potential after continuous subculturing and cryopreservation, Can be used as an ideal seed cells for aging and lesion-induced tissue and organ damage repair.