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观察小柴胡汤、大黄虫丸、鳖甲煎丸对不同时期肝纤维化大鼠血清透明质酸 (hyaluranicAcid ,HA)、层粘蛋白 (Laminin ,LN)及血清Ⅲ型前胶原 (procollagenⅢ ,PcⅢ )影响 ;采用CCl4 肝纤维化模型 ,用放射免疫方法测血清PcⅢ、HA、LN含量 ,结果小柴胡汤预防及肝极轻度损伤时可显著降低血清LN、HA含量 ,示小柴胡汤治肝纤维化当早期用药 ;大黄虫丸对肝纤维化各期给药均可降低血清HA、LN、PcⅢ含量 ,示大黄虫丸对肝纤维化有治疗作用 ;鳖甲煎丸预防及治疗给药能降低血清HA含量 ,对LN、PcⅢ只在治疗用药时有作用 ,且大鼠整体状态差 ,示鳖甲煎丸对肝纤维化预防作用不佳 ,虽有治疗作用 ,但其攻逐伤正 ,临床应用当注意扶益正气。
Observation of Xiao Chaihu Decoction, Dahuang Qichong Pills, and Biejiajian Pills on serum hyaluronic acid (HA), laminin (LN) and serum type III procollagen III (PcIII) in rats with hepatic fibrosis at different stages ) Effect; CCl4 liver fibrosis model was used to measure serum PcIII, HA, and LN levels by radioimmunoassay. Results Xiaochuanchahu Decoction can significantly reduce serum LN and HA levels in the prevention and mild hepatic injury, Xiaochaihu Tang treatment of liver fibrosis When used early; Dahuangqichong Pills can reduce the levels of serum HA, LN, and Pc III in liver fibrosis, indicating that Dahuangqichong Pill has a therapeutic effect on liver fibrosis; Biejiajian Pills can prevent and treat drug administration. Decreasing serum HA levels had effects on LN and Pc III only during treatment, and the overall state of the rats was poor, indicating that Biejiajian Pill had a poor preventive effect on hepatic fibrosis. Although it has a therapeutic effect, its attack and injury are positive. Clinical application should pay attention to positive health.