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目的探讨人参三醇组皂苷(PTS)对大鼠坐骨神经急性损伤后的保护作用。方法建立大鼠坐骨神经挤压伤模型,随机分为PTS 100、50、25 mg/kg剂量组(每组10只),坐骨神经损伤后每日腹腔注射PTS;模型对照组(10只),坐骨神经损伤后每日给予同样剂量的生理盐水;空白对照组(10只),不损伤坐骨神经,每日给予同样剂量的生理盐水。坐骨神经损伤术后1、2、3、4 w观察坐骨神经功能指数(SFI)、运动神经传导速度(MNCV)。结果坐骨神经损伤术后21、30 d PTS 100 mg/kg bw剂量组的SFI分别为-30.2±10.4及-20.0±6.9明显优于模型对照组-52.1±11.0及-46.2±7.8(P<0.05),术后30 d PTS 100 mg/kg bw剂量组的MNCV为14.72±4.34明显优于模型对照组8.27±2.53(P<0.05)。结论人参三醇组皂苷对大鼠坐骨神经急性损伤后有一定的保护作用。
Objective To investigate the protective effect of Panaxtriol saponin (PTS) on acute injury of sciatic nerve in rats. Methods Rat sciatic nerve crush injury models were established and randomly divided into PTS 100, 50 and 25 mg / kg (n = 10), intraperitoneal injection of PTS after sciatic nerve injury, model control group (n = 10), sciatic nerve injury The same dose of saline was given daily. The blank control group (10 rats) did not injure the sciatic nerve and the same dose of saline was given daily. Sciatic nerve function index (SFI) and motor nerve conduction velocity (MNCV) were observed after 1, 2, 3, 4 w of sciatic nerve injury. Results The SFI of PTS 100 mg / kg bw at 21 and 30 days after sciatic nerve injury was -30.2 ± 10.4 and -20.0 ± 6.9 respectively, which was significantly better than that of model control group -52.1 ± 11.0 and -46.2 ± 7.8 (P <0.05) , And the MNCV of PTS 100 mg / kg bw at 30 days after operation was 14.72 ± 4.34, which was significantly better than that of model control group 8.27 ± 2.53 (P <0.05). Conclusion Panaxtriol saponin has some protective effects on acute injury of sciatic nerve in rats.