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为了掌握南宁市新生儿腹泻的特点，有效控制新生儿腹泻，我们于１９８８年３月至１９９３年２月对南宁市内五家医院７８７例新生儿腹泻粪便进行了病原检测，耐药性监测和流行病学分析。检出各种致泻病原体２６１例，总检出率３３．２％。计２４种病原，细菌性感染占９６．６％。社会获得性腹泻检出率为２７．５％，病原性大肠菌占７１．３％，以ＥＰＥＣ为主（８８／１６０）。医院内获得性腹泻检出率４９．０％，以沙门氏菌为主（４５．５％），呈爆发流行；次为ＥＰＥＣ、绿脓杆菌、变形杆菌，呈散发性。根据院内流行发生的主要原因，采取可行性有效措施，院内获得性腹泻发生率由２２．７％降至２．７％，近四年，未超过２．０％。新生儿主要致病菌对最常用的氨苄青霉素、硫酸卡那霉素及庆大霉素的耐药率很高（７６．９～１００．０％），丁胺卡那霉素是目前控制新生儿细菌感染性腹泻最理想的抗生素
In order to grasp the characteristics of neonatal diarrhea in Nanning and effectively control neonatal diarrhea, we conducted 787 neonatal diarrhea stools in five hospitals in Nanning between March 1988 and February 1993 for pathogen detection, drug resistance monitoring and Epidemiological analysis. 261 kinds of diarrhea pathogens were detected, the total detection rate was 33.2%. Count 24 kinds of pathogens, bacterial infections accounted for 96.6%. The rate of community-acquired diarrhea was 27.5%, and that of pathogenic coliforms was 71.3%, with EPEC as the major cause (88/160). The rate of hospital acquired diarrhea was 49.0%, mainly Salmonella (45.5%), with an outbreak epidemic; the second was EPEC, Pseudomonas aeruginosa and Proteus, and was sporadic. According to the major causes of nosocomial epidemics, feasible and effective measures were taken to reduce the incidence of nosocomial diarrhea from 22.7% to 2.7% in the recent four years and not exceeding 2.0%. The main neonatal pathogens of the most commonly used ampicillin, kanamycin sulfate and gentamicin resistance rate (76.9 ~ 100.0%), amikacin is the control of freshmen Bacterial infectious diarrhea, the best antibiotics