不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应研究进展

• 作 者: 陈杰 刘钦 戴小鸯 聂凛凛 房辉辉 吴小余
• 机 构: 上海大学化学系,
• 出 处: 有机化学
• 发表日期: 2013年01期
• 关键词: 串联反应 Michael加成 有机催化 胺化 氮杂多环 不饱和醛 不对称 对映选择性 杂多 有机小分子

随着近十多年来不对称有机小分子催化的发展,以这类催化为基础的串联反应也取得了很大的进展.综述了近几年来不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应构建手性氮杂多环结构的研究进展,介绍了国内外多个课题组对这一类反应的研究结果以及该类反应在生物碱合成中的应用.

With the development of asymmetric small organic molecules catalyzed by asymmetric organic molecules for more than a decade, great progresses have been made in the series reactions based on this kind of catalysis. In this review, the asymmetric organic catalysis of Michael Addition / Hemiamides The progress of the research on the construction of chiral aza polycyclic structure by the cyclization / imide cation cyclization reaction was reviewed. The research results of this kind of reactions by several research groups at home and abroad and the application of such reactions in alkaloid synthesis .