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目的研究大黄酚脂质体的最佳制备工艺和处方,并对其进行质量考察。方法采用薄膜-超声分散法制备大黄酚脂质体,以包封率为评价指标,采用单因素和正交试验法优化大黄酚脂质体的制备处方和工艺条件,并观察其粒径、形态及稳定性。结果大黄酚脂质体优化后的制备处方和工艺条件为:胆固醇与大豆卵磷脂质量比为1∶3,药脂比为1∶10,pH值为8.2,成膜温度为45℃。按该处方工艺制备的大黄酚脂质体包封率在87%以上。结论优选处方和制备工艺稳定可行,制备的大黄酚脂质体包封率和稳定性高,粒径均匀。
Objective To study the optimum preparation technology and prescription of chrysophanol liposomes, and to conduct quality inspection. Methods The chrysophanol liposomes were prepared by the membrane-ultrasonic dispersion method. The encapsulation efficiency was used as the evaluation index. The preparation prescription and process conditions of chrysophanol liposomes were optimized by single factor and orthogonal test. The particle size and morphology And stability. Results Chrysophanol liposomes were prepared by optimizing the formulation and processing conditions as follows: the mass ratio of cholesterol to soybean lecithin was 1: 3, the lipid-lipid ratio was 1:10, the pH value was 8.2, and the film-forming temperature was 45 ℃. According to the prescription process chitosan liposome encapsulation efficiency of 87%. Conclusion The optimal prescription and preparation process are stable and feasible. The prepared chrysophanol liposomes have high encapsulation efficiency and stability and uniform particle size.