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作者报告1例十二指肠溃疡患者口服甲腈咪胍后引起多发性肌炎和急性间质性肾炎。患者男性,42岁黑人,于1982年1月因严重无力数日急诊入院。11个月前因十二指肠溃疡口服甲腈咪胍,300mg,每日3次。起初规则服药,以后间歇服药至1981年12月,此后因溃疡复发规则服药至入院。患者出现肌痛和进行性肌无力已6个月,既往无肾病史。血压140/90,体检发现皮肤有尿素霜,上腹部轻度触痛,近端肌力减退,尤以下肢明显,余无异常。
The authors report that one patient with duodenal ulcer caused episodes of polymyositis and acute interstitial nephritis after oral administration of cimetidine. Male patient, 42 years old black, was admitted to hospital in January 1982 due to severe inability to perform several days of emergency. 11 months ago due to duodenal ulcer oral nitiditine, 300mg, 3 times a day. At first the rules of medication, after intermittent medication to December 1981, since then rule of ulcer recurrence medication to hospitalization. Patients with myalgia and progressive muscle weakness have been 6 months, no previous history of kidney disease. Blood pressure 140/90, physical examination found that the skin with urea cream, mild tenderness in the abdomen, proximal muscle weakness, especially in the lower limbs obvious, I no exception.