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目的回顾性分析某院2008年1月～2010年1月间125例拟诊肺癌患者的临床资料,探讨痰细胞学检查的临床价值。方法将拟诊肺癌的痰涂片,剩余标本制成细胞块,进行石蜡包埋连续切片,其中5例行免疫细胞化学CK5/6、P63、CK7、TTF-1、CD56、Syn染色以明确分型。结果在125例痰液中,鳞状细胞癌46例(占36.8%),小细胞癌21例(16.8%),腺癌12例(9.6%),其他2例(1.6%)(腺鳞癌,大细胞癌各1例),检出率鳞癌﹥小细胞癌﹥腺癌,且高分化鳞癌、中低分化腺癌及中心型肺癌患者阳性率较高。结论所采用的痰涂片与细胞块检查相结合,必要时行免疫细胞化学检查,有效地提高了痰细胞学检查的检出率和准确性,在较短的时间为临床提供较高的参考价值。
Objective To retrospectively analyze the clinical data of 125 patients with suspected lung cancer from January 2008 to January 2010 in a hospital and discuss the clinical value of sputum cytology. Methods Sputum smears of lung cancer were prepared and the remaining specimens were made into cell masses and paraffin-embedded serial sections were obtained. Among them, 5 were immunostained with CK5 / 6, P63, CK7, TTF-1, CD56 and Syn, type. Results Of the 125 sputum samples, 46 (36.8%) had squamous cell carcinoma, 21 (16.8%) had small cell carcinoma, 12 (9.6%) had adenocarcinoma and 2 (1.6%) had adenocarcinoma , 1 case of large cell carcinoma), the detection rate of squamous cell carcinoma> small cell carcinoma> adenocarcinoma, and well-differentiated squamous cell carcinoma, moderately poorly differentiated adenocarcinoma and central lung cancer patients with a higher positive rate. Conclusion Sputum smear combined with cell block examination, if necessary, immunocytochemistry, which effectively improve the detection rate and accuracy of sputum cytology in clinical trials to provide a higher reference value.