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目的检测结肠癌组织中CYP2W1与Survivin的表达情况,并探讨两者之间的相关性。方法选择2010年5月—2012年8月收治的结肠癌患者43例为结肠癌组,同期选择15例良性病变患者的部分结肠组织作为对照组,采用免疫组化法分别检测CYP2W1和Survivin在两组中的表达情况。计数资料采用χ2检验,相关性研究采用Lo-gistic回归分析,P<0.05为差异有统计学意义。结果结肠癌组CYP2W1阳性率为93.0%,对照组CYP2W1阳性率为0.0%,两组比较差异有统计学意义(χ2=40.720,P<0.05)。结肠癌组Survivin阳性率为88.4%,对照组CYP2W1阳性率为13.3%,两组比较差异有统计学意义(χ2=25.856,P<0.05)。结肠癌组CYP2W1与Survivin均表达阳性的为41例;Survivin阳性而CYP2W1阴性的2例,Survivin阴性而CYP2W1阳性的有3例,Survivin和CYP2W1都阴性的有12例,CYP2W1与Survivin在结肠癌组织标本中的表达呈正相关(r=0.40,P<0.05)。结论Survivin和CYP2W1的异常表达可能是导致结肠癌组织细胞凋亡失控、异常增殖潜在性原因之一,是否有协同作用需要进一步的实验验证。
Objective To detect the expression of CYP2W1 and Survivin in colon cancer tissues and to explore the correlation between the two. Methods Forty-three patients with colon cancer who were treated in our hospital from May 2010 to August 2012 were selected as the colon cancer group. Some colon tissues of 15 patients with benign disease were selected as the control group. The expressions of CYP2W1 and Survivin were detected by immunohistochemistry Group expression. Count data using χ2 test, correlation study using Lo-gistic regression analysis, P <0.05 for the difference was statistically significant. Results The positive rate of CYP2W1 in colon cancer group was 93.0%, while the positive rate of CYP2W1 in control group was 0.0%. There was significant difference between the two groups (χ2 = 40.720, P <0.05). The positive rate of Survivin in colon cancer group was 88.4%, while the positive rate of CYP2W1 in control group was 13.3%. There was significant difference between the two groups (χ2 = 25.856, P <0.05). In colon cancer group, 41 cases were positive for CYP2W1 and Survivin, 2 cases were negative for Survivin and negative for CYP2W1, 3 cases were negative for Survivin and 3 cases were positive for CYP2W1, 12 cases were negative for Survivin and CYP2W1, and negative for CYP2W1 and Survivin in colon cancer The expression of the specimen was positively correlated (r = 0.40, P <0.05). Conclusion The abnormal expression of Survivin and CYP2W1 may be one of the potential causes of uncontrolled and abnormal proliferation of colon cancer cells. Whether there is synergism needs further experimental verification.