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目的:解我院药品不良反应(ADR)发生的一般规律及特点,为临床合理用药提供参考。方法:收集我院2007～2009年向北京市药品不良反应监测中心上报的ADR报表135份,按患者性别、年龄、给药途径、药品种类、ADR累及的器官或系统及临床表现、严重ADR、ADR构成比排序居前10位的药品等方面进行统计、分析。结果:135例ADR报告中涉及的药品共14类46种,其中抗微生物药引发的ADR最多(占39.26%);静脉滴注是引发ADR的主要给药途径(占91.11%);皮肤及其附件损害最为常见(占48.15%);严重的ADR 4例(占2.96%)。结论:应重视ADR的报告和监测工作,以减少或避免ADR的发生,促进临床合理用药。
Objective: To understand the general rules and characteristics of drug adverse reactions (ADR) in our hospital and provide reference for clinical rational drug use. Methods: A total of 135 ADR reports were collected from Beijing Institute of Adverse Drug Reactions Monitoring Center from 2007 to 2009. According to the patient’s sex, age, route of administration, drug type, organ or systemic and clinical manifestations of ADR, severe ADR, ADR composition than the top 10 ranked drugs and other aspects of statistics, analysis. Results: Among the 135 ADR cases, 14 of the 46 drugs were involved, of which anti-microbial drug-induced ADR was the most (39.26%); intravenous drip was the main route leading to ADR (91.11%); skin and its Attachment damage is the most common (48.15%); severe ADR 4 cases (2.96%). Conclusion: Pay attention to the report and monitoring of ADR in order to reduce or avoid the occurrence of ADR and promote the rational use of clinical medicine.