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目的探讨T辅助细胞17(Th17)/调节性T细胞(Treg)比值对放射性肺炎发生的预测价值。方法实施直线加速器及多叶光栅实施放疗的胸部肿瘤患者148例分为两组:A组24例,发生放射性肺炎;B组124例,非放射性肺炎。采用流式细胞术检测放疗前、放疗期间及放疗后第4周两组外周血中Th17和Treg细胞水平,计算Th17/Treg比值,比较两组放疗剂量相关参数。结果两组放疗前及放疗期间的Th17和Treg细胞水平均无统计学差异(P>0.05)。放疗后第4周,A组Th17细胞水平高于B组,而Treg细胞水平低于B组(P<0.01)。A组放疗5、6周及放疗后第4周Th17/Treg比值高于B组(P<0.05)。A组放疗剂量相关参数与B组相仿(P>0.05)。结论 Th17/Treg比值可作为放射性肺炎发生的预测因子。
Objective To investigate the predictive value of T helper 17 (Th17) / regulatory T cell (Treg) ratio in the pathogenesis of radiation pneumonitis. Methods A total of 148 cases of thoracic tumors undergoing radiotherapy with linear accelerator and multi-lobed gratings were divided into two groups: 24 cases in group A with radiation pneumonitis; 124 cases in group B with non-radioactive pneumonia. Flow cytometry was used to detect the levels of Th17 and Treg cells in peripheral blood before radiotherapy, during radiotherapy and 4 weeks after radiotherapy, and the Th17 / Treg ratio was calculated. The dose-related parameters were compared between the two groups. Results There was no significant difference in Th17 and Treg cell levels between the two groups before and during radiotherapy (P> 0.05). In the fourth week after radiotherapy, the level of Th17 cells in group A was higher than that in group B, while the level of Treg cells was lower in group A than in group B (P <0.01). The ratio of Th17 / Treg in group A was higher than that in group B (P <0.05) at the 5th, 6th week and the 4th week after radiotherapy. The dose-related parameters in group A were similar to those in group B (P> 0.05). Conclusion Th17 / Treg ratio can be used as a predictor of radiation pneumonitis.