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可乐定(Clonidine)是应用较普遍的中枢性降压药,近来,国内外发现它具有一些非抗高血压方面的新用途。 治疗溃疡性结肠炎 可乐定0.3mg/d,分3次服用,对重度特发性溃疡性结肠炎有良效。且疗效与血浆皮质醇水平的降低相平行,亦与结肠内张力的增高相平行。 治疗慢性腹泻 对3例特发性糖尿病腹泻病人用多种药物治疗无效后,试用可乐定0.2mg/d,最大可渐增至1.0mg/d,均分2次给药,结果3例病人大便量、大便次数均明显较治疗前减少。
Clonidine is the most commonly used central antihypertensive drug, and recently it has been found at home and abroad that it has some new uses that are not anti-hypertensive. Treatment of ulcerative colitis clonidine 0.3mg / d, taken 3 times, for severe idiopathic ulcerative colitis have good effect. And efficacy and plasma cortisol levels parallel to the reduction, but also with the increase of intracolonic tension parallel. Treatment of chronic diarrhea 3 idiopathic diabetes diarrhea patients with multiple drug treatment fails, the trial of clonidine 0.2mg / d, the maximum can be increased to 1.0mg / d, were divided into two doses, the results of 3 patients stool Volume, stool frequency were significantly reduced compared with before treatment.