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目的探讨雷帕霉素药物洗脱支架在老年急性冠状动脉综合征患者经皮冠状动脉介入治疗(PCI)中应用的安全性和有效性。方法对112例年龄75岁以上的急性冠状动脉综合征患者的125处罪犯病变行PCI治疗,共置入了140枚雷帕霉素药物洗脱支架。结果112例PCI均成功,未发生与PCI有关的并发症。2例于术后18 h内死于心源性休克,1例术后第3天死于心脏破裂,未发生主要不良心血管事件。进行1年临床随访,有1例术后3个月发生猝死,另有2例术后5个月再次行冠状动脉血管重建术,无其他主要不良心血管事件发生。结论雷帕霉素药物洗脱支架在老年急性冠状动脉综合征患者的急诊PCI中应用有较强的安全性和有效性。
Objective To investigate the safety and efficacy of rapamycin eluting stent in percutaneous coronary intervention (PCI) in elderly patients with acute coronary syndrome. Methods A total of 125 rapamycin-eluting stents were enrolled in 125 criminal cases of 112 patients with acute coronary syndrome who were over 75 years of age. Results 112 cases of PCI were successful, no PCI-related complications. Two patients died of cardiogenic shock within 18 hours after operation, and one died of cardiac rupture on the third day after operation. No major adverse cardiovascular events occurred. One year clinical follow-up showed that 1 patient died of sudden death 3 months after operation, and another 2 patients underwent coronary revascularization 5 months after operation. No other major adverse cardiovascular events occurred. Conclusion Rapamycin-eluting stent has strong safety and efficacy in the emergency PCI of elderly patients with acute coronary syndrome.