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AIM: To explore the long-term therapeutic effects of surgical treatmeut foristhnic spondylolisthesis. METHODS: 42 cases of isthunic spondylolisthesiswere analyzed retrospectively among which 13 cases underwent simple lum-bar interlaminar bone implant and 29 cases underwent transpecdicular fixationcombined with bone implantation. Assessment was made according to JOAstandards before and after treatment. RESULTS: At a 3 years of follow-upassessment, the functional outcome in transpedicular fixation assessed byJOA was excellent and good in 79.3% as compared with the group withoutfixation in which the excellent and good result was 76. 9%. The level of painand functional disability were similar in the two groups, but fusion rate in thegroup with transpedicular fixation was higher than that in group withoutit. CONCLUSION: Surgical treatment for isthmic spondylolisthesis improvesfunction and relieves pain.