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高危型人乳头状瘤病毒(HPV)感染与宫颈癌发生密切相关。由于HPVL1蛋白结构保守,含多个抗原表位,在真核及原核细胞中表达后能自我装配形成病毒样颗粒(VLP),其结构和抗原表位与天然的病毒颗粒十分相似,能刺激机体产生保护性抗体,是HPV预防性疫苗的主要靶抗原。目前上市的HPV-VLPs疫苗主要是从昆虫细胞和酵母细胞中表达纯化,该类疫苗具备很高的安全性和免疫原性,能够有效地预防相应型别HPV持续感染及其引发的宫颈癌。但该类疫苗成本很高,受经济条件限制,这种疫苗很难在发展中国家广泛应用。
High-risk human papilloma virus (HPV) infection and cervical cancer are closely related. Because HPVL1 protein is conserved in structure and contains multiple epitopes, HPVL1 can self-assemble to form virus-like particles (VLPs) after expression in eukaryotic and prokaryotic cells. The structure and epitope of HPV L1 protein are very similar to those of natural virus particles and can stimulate the body Producing protective antibodies, is the primary target antigen for HPV prophylactic vaccines. Currently, HPV-VLPs vaccines are mainly expressed and purified from insect cells and yeast cells. Such vaccines have high safety and immunogenicity and can effectively prevent persistent HPV infection and cervical cancer. However, the cost of such vaccines is very high. Due to the economic constraints, such vaccines are very difficult to be widely used in developing countries.