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为寻求有助于早期诊断新生儿败血症的方法 ,我们采用 EL ISA方法检测了 2 7例败血症新生儿血清 IL- 6、TNF- α水平 ,并与 30例对照组新生儿进行比较。结果表明 :败血症患儿血清 IL - 6、TNF-α水平均显著高于对照组新生儿。同时还发现败血症患儿 IL- 6的敏感性显著高于 TNF- α。另外 ,IL- 6与 CRP与联合诊断新生儿败血症的敏感性达 1 0 0 %。提示细菌感染时患儿血中 IL- 6、TNF-α升高 ,在新生儿败血症病程初期同时检测 IL - 6和 CRP对早期诊断有帮助
In order to find a way to help early diagnosis of neonatal sepsis, ELISA method was used to detect serum IL-6 and TNF-α levels in 27 neonates with sepsis and compared with 30 control neonates. The results showed that the levels of serum IL - 6 and TNF - α in sepsis children were significantly higher than those in the control group. Also found that children with sepsis IL-6 sensitivity was significantly higher than TNF-α. In addition, IL-6 and CRP and combined diagnosis of neonatal sepsis sensitivity of up to 100%. It is suggested that IL-6 and TNF-α in blood of children with bacterial infection are elevated, and simultaneous detection of IL-6 and CRP in early stage of neonatal sepsis may be helpful for early diagnosis