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The inclusion complexations of β-cyclodextrin with four hyoseyarnine drugs wereinvestigated by microcalorimetric technique and ~1HNMR.All the inclusion complexes were foundto be 1:1 and their thermodynamic parameters of formation constant K,△G°,△H°and △S°wereobtained.The ~1HNMR spectra strongly suggested that the drug molecule is included in the hydro-phobic cavity of β-cyclodextrin.The properties of binding force and effects of steric hindranceand chirality of the drugs on the inclusion complexation were also discussed.
The inclusion complexations of β-cyclodextrin with four hyoseyarnine drugs were investigated by microcalorimetric technique and ~ 1HNMR. All the inclusion complexes were found to be 1: 1 and their thermodynamic parameters of formation constant K, ΔG °, ΔH ° and ΔS ° wereobtained The ~ 1HNMR spectra strongly suggested that the drug molecule is included in the hydro-phobic cavity of β-cyclodextrin. The properties of binding force and effects of steric hindrance and chirality of the drugs on the inclusion complex were also discussed.