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目的：观察松果腺功能低下大鼠的细胞免疫的变化及白芍总甙（ＴＧＰ）的作用。方法：主要应用傍晚腹腔注射普萘洛尔或大鼠双侧颈上神经节切除造成松果腺功能低下的模型。结果：下午４：００腹腔注射普萘洛尔（１５ｍｇ·ｋｇ－１·ｄ－１×７ｄ）可引起Ｔ、Ｂ淋巴细胞转化率降低、ＴＧＰ（２０ｍｇ·ｋｇ－１·ｄ－１，ｉｐ或５０ｍｇ·ｋｇ－１·ｄ－１ｐｏ）能使普萘洛尔降低的Ｔ、Ｂ淋巴细胞免疫功能恢复正常；双侧颈上神经节切除造成大鼠胸腺及脾淋巴细胞的致分裂素反应降低，ＩＬ－２生成减少、ＴＧＰ（２０ｍｇ·ｋｇ－１·ｄ－１ｉｐ或５０ｍｇ·ｋｇ－１·ｄ－１ｐｏ）可反转双侧颈上神经节切除的作用。结论：ＴＧＰ的免疫调节作用与松果腺有关。
Objective: To observe the changes of cellular immunity in pineal gland dysfunction rats and the effect of total glucosides of paeony (TGP). Methods: The main application of evening intraperitoneal injection of propranolol or rat bilateral cervical supracondylar ganglion resulting in the model of pineal gland dysfunction. Results: Intraperitoneal injection of propranolol (15 mg · kg -1 · d -1 × 7 d) at 4:00 pm caused a decrease in the T, B lymphocyte transformation rate. TGP (20 mg · kg -1 · d -1, ip or 50mg · kg-1 · d-1po) can make propranolol reduce T, B lymphocyte immune function returned to normal; bilateral cervical supernuclear ganglionectomy induced thymus and spleen lymphocyte mitogen-induced response decreased, IL-2 production was reduced, TGP (20mg · kg-1 · d-1ip or 50mg · kg-1 · d-1po) can reverse the effect of bilateral cervical supra-ganglionectomy. Conclusion: The immunomodulatory effect of TGP is related to pineal gland.