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目的探讨游离PSA/总PSA(f/t)<0.16对于总PSA≤4ng/ml的前列腺癌(PCa)患者是否具有指导前列腺穿刺的意义。方法回顾本院于2008年至2014年收治的总PSA≤4ng/ml的PCa患者的病历资料,分为4组,A组:f/t<0.16;B组:f/t<0.16且MRI或DRE阳性;C组:f/t≥0.16;D组:f/t≥0.16且MRI或DRE阳性。统计各组穿刺者人数及穿刺阳性率。结果共计73人进入本研究,A组32人,穿刺阳性率23.5%;B组9人,穿刺阳性率33.3%;C组41人,穿刺阳性率11.5%;D组12人,穿刺阳性率16.7%。A组与B组,A组与C组,B组与D组之间穿刺阳性率差别有统计学意义(P<0.05)。C组与D组穿刺阳性率差别无统计学意义(P>0.05)。结论对于总PSA≤4ng/ml的PCa患者,f/t<0.16可以作为前列腺穿刺的指导指标,联合MRI或DRE检查可以提高前列腺穿刺阳性率。
Objective To investigate whether the value of free PSA / total PSA (f / t) <0.16 in prostate cancer (PCa) patients with total PSA≤4ng / ml has the significance of guiding prostate biopsy. Methods The data of PCa patients with total PSA ≤4ng / ml admitted in our hospital from 2008 to 2014 were retrospectively divided into four groups, group A: f / t <0.16; group B: f / t <0.16 and MRI or DRE positive; C group: f / t≥0.16; D group: f / t≥0.16 and MRI or DRE positive. Statistics of the number of puncture and puncture the positive rate of each group. Results A total of 73 patients entered the study. A group of 32 people, the puncture positive rate was 23.5%; B group of 9 people, the puncture positive rate was 33.3%; C group 41, puncture positive rate was 11.5%; D group, puncture positive rate was 16.7 %. There was a significant difference in the positive rate of puncture between group A and group B, group A and group C, group B and group D (P <0.05). There was no significant difference in the positive rate of puncture between group C and group D (P> 0.05). Conclusion For PCa patients with total PSA less than 4ng / ml, f / t <0.16 may be used as a guideline for prostate biopsy, and combined with MRI or DRE may improve the positive rate of prostate biopsy.