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目的:对比早发和迟发2型糖尿病(diabetesmellitustype2,T2DM)患者并发糖尿病微血管病变(diabeticmicroangiopathy,DMAP)及生化项目差异,探讨其临床特点。方法:选择临床确诊的住院和门诊T2DM患者160例,分为早发组(诊断年龄≤40岁)和迟发组(诊断年龄>40岁),比较并发DMAP及生化项目的差异。结果:早发组T2DM患者并发DMAP阳性率显著高于迟发组T2DM患者(χ2=4.304,P<0.05)。早发组T2DM患者HbA1c和TG水平显著高于迟发组T2DM患者(P<0.01);LDLC水平显著低于迟发组T2DM患者(P<0.01)。早发组与迟发组相比FPG、2hPG、TC及LDLC水平差异无显著性(P>0.05)。结论:早发T2DM患者较迟发者有更严重的代谢紊乱和易并发糖尿病微血管病变的临床特点,此为早期干预早发T2DM患者各种危险因素,减少DMAP的发生提供了理论依据。
OBJECTIVE: To compare the differences of diabetic microangiopathy (DMAP) and biochemical items in patients with early-onset and late-onset type 2 diabetes mellitus (T2DM) and explore their clinical features. Methods: 160 clinically diagnosed inpatients and outpatients with T2DM were divided into two groups: early onset group (age ≤40 years) and late group (age> 40 years). The differences between DMAP and biochemical items were compared. Results: The positive rate of DMAP in T2DM patients in early onset group was significantly higher than that in T2DM patients in late onset group (χ2 = 4.304, P <0.05). The levels of HbA1c and TG in T2DM patients in early onset group were significantly higher than those in T2DM patients in late onset group (P <0.01). The levels of LDLC in T2DM patients in early onset group were significantly lower than those in T2DM patients in late onset group (P <0.01). There was no significant difference in FPG, 2hPG, TC and LDLC between early onset group and late onset group (P> 0.05). CONCLUSIONS: The early onset T2DM patients have more serious metabolic disorders and clinical features of diabetic microangiopathy compared with the later ones. This provides a theoretical basis for the early intervention of various risk factors in patients with T2DM and the reduction of DMAP.