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目的探讨幽门螺杆菌(H.pylori)感染性消化性溃疡(peptic ulcer,PU)与ABO血型及胃肠激素的相关关系。方法随机选择217例消化性溃疡患者为研究组(PU组)和236例健康志愿者为对照组,分别采用放射免疫法和微柱凝胶法检测胃泌素、生长抑素水平和ABO血型,比较ABO血型胃泌素、生长抑素水平和H.pylori感染的差异。结果PU组O型血者占48.85%,明显高于O型血在正常人群中的分布(32.20%,P<0.05);无论是消化性溃疡患者还是健康者,O型血人群的H.pylori感染率均显著高于非O血型(P<0.05-0.01);O型对照组胃泌素水平比非O型各组高,但无显著性差异(P>0.05);对照各组生长抑素水平无差异(P>0.05);而PU组O型胃泌素水平升高,与各对照组相比有显著性差异(P<0.05);PU组O型生长抑素水平则下降,与其他各组相比有显著性差异(P<0.05)。结论 ABO血型中O型血者易患消化性溃疡,幽门螺杆菌的易感性及胃肠激素分泌紊乱是关键因素.
Objective To investigate the relationship between H. pylori infection peptic ulcer (PU) and ABO blood type and gastrointestinal hormones. Methods A total of 217 patients with peptic ulcer were randomly selected as study group (PU group) and 236 healthy volunteers as control group. Gastrin, somatostatin and ABO blood type were detected by radioimmunoassay and micro-column gel method respectively. Differences in ABO blood gastrin, somatostatin levels, and H. pylori infection were compared. Results The percentage of O-type blood in PU group was 48.85%, which was significantly higher than that of O-type blood in normal population (32.20%, P <0.05). H.pylori (P <0.05-0.01). Gastrin level in O group was higher than that in non-O group, but there was no significant difference (P> 0.05). The levels of somatostatin (P> 0.05). However, the level of O-type gastrin in PU group increased significantly compared with that in control group (P <0.05). The level of O-type somatostatin in PU group decreased, There was significant difference between each group (P <0.05). Conclusions OO blood in ABO blood group is susceptible to peptic ulcer, the susceptibility of Helicobacter pylori and disorders of gastrointestinal hormone secretion are the key factors.