Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice

• 作 者: Ji Zhang Chunlin Yan Shu Wang Yong Hou Guiping Xue Li Zhang
• 机 构: Department of Pharmacology, Hebei North University,
• 出 处: Neural Regeneration Research
• 发表日期: 2014年09期
• 关键词: neonatal hippocampal exposed superoxide glutathione endoplasmic exposure neurona

Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol(0.1, 1.0, 10.0 mg/kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.

Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation , Chrysophanol (0.1, 1.0, 10.0 mg / kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol also alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment Collectively, these findings indicate that chrysophanol can significantl y reduce damage to hippocampal neurons in lead-exposed neonatal mice.