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目的通过对2416例不孕不育、有遗传病或家族史以及不良孕产史患者的染色体结果调查,探讨平衡易位与临床效应关系。方法取外周血进行淋巴细胞培养,染色体G显带分析。结果共发现异平衡易位29例(罗伯逊易位5例),占1.20%。结论染色体平衡易位是导致不孕不育、自然流产及死胎、生育异常儿的重要原因之一,对这类人群进行遗传优生和产前诊断及辅助生殖指导等有针对性的检查和临床干预是非常必要的。
Objective To investigate the relationship between the equilibrium translocation and clinical effect through the investigation of chromosome results of 2416 cases of infertility, genetic diseases or family history and poor pregnancy history. Methods Peripheral blood was taken for lymphocyte culture and chromosome G banding analysis. Results We found a total of 29 cases of heterogeneous translocation (Robertson translocation in 5 cases), accounting for 1.20%. Conclusions Chromosomal balance translocation is one of the most important causes of infertility, spontaneous abortion and stillbirth and abnormal childbirth. Targeted examination and clinical intervention such as genetic prenatal and prenatal diagnosis and assisted reproductive guidance It is very necessary.