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Background Non-infectious fever in patients with aortic dissection after endovascular aortic repair (EVAR) is very common and can cause a series of adverse effects.However,the etiology and pathophysiology of non-infectious postoperative fever is seldom studied.Methods According to predefined criteria,148 patients underwent EVAR were divided into two groups:non-infectious fever group and non-fever group.Clinical data were compared between groups and multiple logistic regressions were performed to detect the risk factors of noninfectious fever.Results A total of 54.1％ (80/148) EVAR patients suffered non-infectious fever.Fever (37.3-38 ℃) was almost universally presented in 57.5％ patients.And 37.5％ of the patients had fever ranging from 38.1 to 39 ℃ and 5％ of the patients had fever above 39℃.Increased levels of D-dimer,white blood cell count (WBC),procalcitonin (PCT),C-reactive protein (CRP),operation time duration and the length of stents and decreased levels of hemoglobin were presented in the non-intectious fever group as compared to non-fever group (P＜0.005).Multiple logistic regression analysis revealed that D-dimer (OR=2.533,P=0.031),PCT (OR=3.307,P=0.009),operation time duration (OR=2.631,P=0.021) and the length of stents (OR=2.851,P=0.015) were independently associated with non-infective fever EVAR.Furthermore,we also found that the duration of stay in CCU (3.2±2.2 vs.2.5±2.0),hospital time (8.6±2.2 vs.7.5±2.3) and hospitalization expense (131.2 ± 30.8 vs.120.6 ± 25.9 thousand yuan) were significant different between the two groups.Conclusions Increased levels of D-dimer,procalcitonin concentration,operation duration and the length of stents are risk factors for non-infectious fever of EVAR,which may prolong the duration of stay in CCU and hospital,and increase the hospitalization expense.