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探讨大剂量地塞米松（ＤＥＸ）及静注免疫球蛋白（ＩＶＩＧ）治疗特发性血小板减少性紫癜（ＩＴＰ）的疗效及其对血液粘稠度的影响。以ＤＥＸ、ＩＶＩＧ、ＩＶＩＧ加ＤＥＸ治疗ＩＴＰ患儿，观察其血小板数变化，并于治疗前后各抽取静脉血一次。结果显示：１．平均血小板计数升至正常时间：单纯ＤＥＸ治疗组为７天，单纯ＩＶＩＧ组及ＩＶＩＧ加ＤＥＸ组为４天；平均计数峰值：单纯ＩＶＩＧ组及ＩＶＩＧ加ＤＥＸ组高于ＤＥＸ组，但单纯ＩＶＩＧ组与ＩＶＩＧ加ＤＥＸ组之间无显著差异。２．ＩＴＰ患儿治疗后骨髓成熟产板巨核细胞数比例由１．５６±２．５３％升至１３．３６±６．６８％，原幼巨核细胞数比例由４０．２０±１．８７％降至１３．３９±９．２８％，差异非常显著，治疗后各组间骨髓巨核细胞数比例无显著差异。３．ＩＴＰ患儿全血粘度值、血浆粘度值治疗前后三组均无显著变化。结论：ＩＴＰ患儿ＩＶＩＧ治疗较ＤＥＸ治疗血小板上升迅速，上升幅度大。１ＶＩＧ治疗的同时加大剂量ＤＥＸ治疗，未能进一步使血小板升高。
To investigate the curative effect of high-dose dexamethasone (DEX) and intravenous immunoglobulin (IVIG) on idiopathic thrombocytopenic purpura (ITP) and its effect on blood viscosity. The patients with ITP were treated with DEX, IVIG, IVIG and DEX, and the change of platelet count was observed. Venous blood was taken before and after treatment. The result shows: 1. Mean platelet count increased to normal time: DEX treatment group was 7 days, IVIG group and IVIG plus DEX group for 4 days; average peak counts: IVIG group and IVIG plus DEX group higher than DEX group, but IVIG group and There was no significant difference between IVIG plus DEX group. 2. The percentage of mature megakaryocytes in bone marrow of ITP children increased from 1.56 ± 2.53% to 13.36 ± 6.68%, and the proportion of immature megakaryocytes decreased from 40.20 ± 1.87% to 13.39 ± 9.28%, the difference was very significant. There was no significant difference in the proportion of bone marrow megakaryocytes between the two groups after treatment. 3. ITP children with whole blood viscosity, plasma viscosity before and after treatment were no significant changes in the three groups. Conclusions: IVIG treatment in ITP patients increases rapidly and increases more rapidly than DEX treatment. 1VIG treatment while increasing the dose of DEX treatment, failed to further platelets.