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脑钠肽(brain natriuretic peptide,BNP)是近年倍受关注的心血管生物标记物,BNP是一种主要由心脏分泌的肽类激素,在心脏维持其正常结构和功能的中起着重要的作用,它具有利钠、利尿、扩血管、降压、拮抗RAAS系统、抑制交感神经兴奋等作用。它已超过原来仅作为心衰的诊断检测指标范畴。研究表明BNP与呼吸困难的鉴别诊断、心肌梗死、高血压、心房颤动、心肌病、肺栓塞等关系密切,现就BNP的临床研究进展作一综述。
Brain natriuretic peptide (BNP) is a cardiovascular biomarker of great interest in recent years. BNP is a peptide hormone secreted mainly by the heart and plays an important role in the heart’s maintenance of its normal structure and function , Which has sodium, diuretic, vasodilator, antihypertensive, antagonistic RAAS system, inhibit sympathetic activity and so on. It has exceeded the original only as a diagnostic indicator of heart failure category. Studies have shown that BNP and differential diagnosis of dyspnea, myocardial infarction, hypertension, atrial fibrillation, cardiomyopathy, pulmonary embolism are closely related to the progress of clinical research BNP are reviewed.