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目的:观察阿托伐他汀对自发性高血压大鼠(SHR)去外膜血管重塑的影响和血管反应性。方法:36只16周龄雄性SHR去除一侧颈动脉外膜后,随机分为3组:阿托伐他汀组、缬沙坦组和对照组,分别灌胃给药4和8周后处死。给药前及给药后每2周测量大鼠安静清醒状态下尾动脉收缩压;给药后第4和8周电磁血流仪测量双侧颈动脉血流量。结果:给药前,各组收缩压差异无统计学意义(P>0.05),给药后第4周,阿托伐他汀组收缩压下降,至第6、8周时[(166.17±7.20)、(159.00±11.21)mmHg]较对照组[(183.50±8.46)mmHg]显著下降(P<0.05,P<0.01);去外膜侧第4周血管阻力指数轻度降低,第8周时略大于正常侧;阿托伐他汀组和缬沙坦组[(4.937±0.359),(3.673±0.161)]均较对照组(5.327±0.371)显著减小(P<0.05,P<0.01)。结论:SHR去外膜后早期血管阻力轻度下降,至后期略有升高,阿托伐他汀可显著降低SHR的血管阻力,包括未去外膜血管。
Objective: To observe the effect of atorvastatin on extravascular angiogenesis remodeling and vascular reactivity in spontaneously hypertensive rats (SHR). Methods: Thirty-six male SHRs at 16 weeks of age were divided into three groups randomly: atorvastatin group, valsartan group and control group. The rats were sacrificed 4 and 8 weeks after gavage respectively. The caudal artery systolic pressure was measured before and after 2 weeks of administration in rats. The bilateral carotid blood flow was measured by electromagnetic flowmeter at the 4th and 8th week after administration. Results: The systolic blood pressure in each group had no significant difference before treatment (P> 0.05). At 4 weeks after administration, the systolic blood pressure in atorvastatin group decreased to the sixth and eighth weeks [(166.17 ± 7.20) , (159.00 ± 11.21) mmHg] compared with the control group [(183.50 ± 8.46) mmHg] (P <0.05, P <0.01). At the fourth week, the vascular resistance index decreased slightly. (4.937 ± 0.359) and (3.673 ± 0.161) in atorvastatin group and valsartan group were significantly lower than those in control group (5.327 ± 0.371, P <0.05, P <0.01). CONCLUSIONS: Early vascular resistance to SHR decreases slightly after adventitia and slightly increases to the late stage. Atorvastatin can significantly reduce vascular resistance of SHR, including the absence of adventitial vessels.