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目的了解肺结核(pulmonary tuberculosis PTB)合并糖尿病(diabetes mellitus,DM)的患者在治疗中肾功能功损害情况,为临床治疗提供参考依据。方法对我院收治59例PTB合并DM患者,临床应用抗结核药物而诱发肾功能损害的资料进行回顾性分析。结果 PTB合并DM的患者中的糖化血红蛋白(HbA1C)升高24人、N-乙酰-β-D氨基葡萄糖苷酶(NAG)升高36人、半胱氨酸蛋白酶抑制剂C(CysC)升高49人、视黄醇结合蛋白(RBP)升高35人;单纯PTB的患者中HbA1C升高7人、NAG升高25人、CysC升高16人、RBP升高24人,PTB合并DM的患者明显高于单纯PTB的患者,P<0.05,有统计学差异。结论 PTB合并DM治疗时应严格控制血糖水平,减少其引起的肾损害影响。
Objective To understand the damage of renal function in patients with pulmonary tuberculosis (PTB) and diabetes mellitus (DM), and to provide a reference for clinical treatment. Methods A retrospective analysis of 59 cases of PTB with DM in our hospital, clinical application of anti-TB drugs induced renal dysfunction were retrospectively analyzed. Results HbA1C was increased by 24 in patients with PTB combined with DM, 36 in N-acetyl-β-D-glucosaminidase (NAG) and 36 in cystatin C (CysC) 49 and retinol binding protein (RBP) increased by 35; in patients with PTB alone, HbA1C increased by 7, NAG increased by 25, CysC increased by 16, RBP increased by 24, PTB patients with DM Significantly higher than pure PTB patients, P <0.05, with statistical differences. Conclusion PTB combined with DM treatment should be strictly controlled blood glucose levels and reduce the impact of renal damage caused by it.