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目的 研究慢性肝病的内毒素血症发生率以及乳酸菌素治疗的效果。方法 用鲎试验 (L L T)检测。结果 检测 117例临床各类型慢性肝病的肠源性内毒素血症阳性率 ,结果为 40 %～ 80 % ,以重症肝炎最高。内毒素与肿瘤坏死因子互为因果对肝病发生发展产生重要影响。检测结果显示慢性肝病 L L T阳性病人 TNF- a较 L L T阴性及正常人明显提高 ,差别有显著性 (p<0 .0 5 ) ,应用乳酸菌素治疗肝病肠源性内毒血症 30例 ,鲎试验转阴率为 70 .6 % ,显著高于对照组的 6 .6 % ,P<0 .0 1。结论 乳酸菌素可作为肝病的辅助治疗的有效药物之一。
Objective To study the incidence of endotoxemia in chronic liver disease and the effect of lactobacillus treatment. The method of test (L L T) test. Results The positive rate of enterogenous endotoxemia in 117 cases of various types of chronic liver diseases was detected. The result was 40% -80%, with the highest incidence of severe hepatitis. Endotoxin and tumor necrosis factor each other cause and effect on the development of liver disease has a significant impact. The results showed that TNF-a in patients with LLT-positive chronic liver disease was significantly higher than that in LLT-negative and normal subjects, with significant difference (p <0.05). Lactic acid was used in the treatment of 30 patients with hepatogenic intestinal endotoxemia, The negative conversion rate was 70.6%, which was significantly higher than that of the control group (6.6%, P <0.01). Conclusion Lactobacillus can be used as adjuvant therapy of liver disease, one of the effective drugs.