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目的:探讨纳洛酮对急性颅脑损伤患者的临床表现。方法:将我科内治疗的26例急性型颅脑损伤患者随机分为治疗组与对照组各13例。治疗组患者采取纳洛酮静脉注射。对照组采用常规治疗。观察比较两组的意识觉醒恢复时间、存活率、伤残率及死亡率。并记录分析。结果:治疗组意识恢复时间为(7.43±3.54)d,对照组为(10.40±3.91)d,组间比较,差异有统计学意义(P<0.05)。GCS评分(伤愈后3个月内,P<0.05。),治疗组13例,死亡2例,重度残疾为3例,其死亡率为15.38%,重度残疾率为23%;参照组采用常规方法治疗,死亡率为4例,约占30.77%,重度残疾为5例,38.46%。结论:纳络酮能够降低重型颅脑损伤死亡率和重度残疾率,能够加快神经系统的恢复以及意识清醒的速度,值得在基础普遍推广。
Objective: To investigate the clinical manifestations of naloxone in patients with acute craniocerebral injury. Methods: Twenty-six patients with acute craniocerebral injury treated in our department were randomly divided into treatment group (n = 13) and control group (n = 13). Patients in the treatment group received naloxone intravenously. Control group using conventional treatment. Observe and compare the recovery time of conscious awakening, survival rate, disability rate and mortality in both groups. And record analysis. Results: The recovery time was (7.43 ± 3.54) days in the treatment group and (10.40 ± 3.91) days in the control group, the difference was statistically significant (P <0.05). GCS score (3 months after injury, P <0.05), the treatment group of 13 patients, 2 patients died, 3 patients with severe disability, the mortality rate was 15.38%, severe disability rate was 23%; the reference group using conventional Methods of treatment, the mortality rate was 4 cases, accounting for 30.77%, severe disability in 5 cases, 38.46%. Conclusion: Naloxone can reduce the mortality and severe disability rate of severe craniocerebral injury, accelerate the recovery of the nervous system and the speed of consciousness, which deserves universal promotion.