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目的探讨抗中性粒细胞胞浆抗体(antineutrophil cytoplasmic antibody,ANCA)异常对诊断系统性红斑狼疮(systemic lupus erythematosus,SLE)肾功能损害患者的临床意义。方法采用间接免疫荧光法(indirect immunofluorescence,IIF)检测抗中性粒细胞胞浆抗体并对其结果进行回顾性分析。结果 SLE患者ANCA阳性率是35.2%,与混合性结缔组织病(mixed connective tissue disease,MCTD)和其他自身免疫病患者相比,有统计学差异(P<0.01)。SLE患者ANCA阳性组中,p-ANCA与c-ANCA阳性率有统计学差异(P<0.01)。ANCA阳性组与阴性组比较,肾功能损害发生率明显升高(P<0.05)。结论血清p-ANCA抗体检测对诊断SLE患者早期发现及防范肾毒性损害有重要意义。
Objective To investigate the clinical significance of abnormal antineutrophil cytoplasmic antibody (ANCA) in the diagnosis of renal dysfunction in patients with systemic lupus erythematosus (SLE). Methods Anti-neutrophil cytoplasmic antibodies were detected by indirect immunofluorescence (IIF) and the results were retrospectively analyzed. Results The positive rate of ANCA in patients with SLE was 35.2%, which was significantly different from that of mixed connective tissue disease (MCTD) and other autoimmune diseases (P <0.01). The positive rate of p-ANCA and c-ANCA in ANCA-positive SLE patients was statistically significant (P <0.01). ANCA positive group and negative group, the incidence of renal damage was significantly increased (P <0.05). Conclusion The detection of serum p-ANCA antibody is of great significance in diagnosing early detection of SLE patients and preventing nephrotoxicity.